Maternal Deprivation Increases Vulnerability to Morphine Dependence and Disturbs the Enkephalinergic System in Adulthood
نویسندگان
چکیده
منابع مشابه
Maternal deprivation increases vulnerability to morphine dependence and disturbs the enkephalinergic system in adulthood.
Maternal deprivation can trigger long-lasting molecular and cellular modifications in brain functions and might facilitate the appearance of pathogenic behaviors. This study focuses on the vulnerability to develop morphine dependence in adult rats that were separated from their mother and littermates for 3 h per day for 14 d after birth and examines the adaptive changes in the enkephalinergic p...
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Differential regulation of morphine antinociceptive effects by endogenous enkephalinergic system in the forebrain of mice
BACKGROUND Mice lacking the preproenkephalin (ppENK) gene are hyperalgesic and show more anxiety and aggression than wild-type (WT) mice. The marked behavioral changes in ppENK knock-out (KO) mice appeared to occur in supraspinal response to painful stimuli. However the functional role of enkephalins in the supraspinal nociceptive processing and their underlying mechanism is not clear. The aim ...
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ژورنال
عنوان ژورنال: Journal of Neuroscience
سال: 2005
ISSN: 0270-6474,1529-2401
DOI: 10.1523/jneurosci.4807-04.2005